Compound Detail
CHEMBL454241
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Basic Information
| ChEMBL ID | CHEMBL454241 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ICKGZXSYHSVKJW-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
294.7
MW (Da)
2.12
ALogP
5
HBA
1
HBD
77.2
PSA (Ų)
0.79
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 5.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Ki | 5.57 | 5.57 | 2698.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | Ki | = | 2698.0 | nM | 5.57 | Inhibition of Pim1 | 18790640 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18790640 | 10.1016/j.bmcl.2008.08.079 | Serine/threonine-protein kinase pim-1 | 1 |
| 18790640 | 10.1016/j.bmcl.2008.08.079 | Serine/threonine-protein kinase pim-2 | 1 |
Data from ChEMBL 36 via Core Engine