Compound Detail
CHEMBL4548987
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Basic Information
| ChEMBL ID | CHEMBL4548987 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HOOLEAZKFKSGHG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
309.3
MW (Da)
2.09
ALogP
6
HBA
1
HBD
96.1
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysine-specific demethylase 5A CHEMBL2424504 | IC50 | 7.5 | 7.5 | 31.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysine-specific demethylase 5A | IC50 | = | 31.6 | nM | 7.5 | Inhibition of KDM5A (unknown origin) | 27406798 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27406798 | 10.1016/j.bmcl.2016.06.078 | Unchecked | 1 |
| 27406798 | 10.1016/j.bmcl.2016.06.078 | Lysine-specific demethylase 5A | 1 |
Data from ChEMBL 36 via Core Engine