Compound Detail

CHEMBL4561184

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CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL4561184
Phase	Preclinical
Structure Type	MOL
InChI Key	HIOICWZYZDBHEL-ZLABENONSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

1895.2

MW (Da)

Drug Information

Molecule Type	Unknown
Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C89H131N13O30S
MW	1895.16

Activity Summary

IC50 2 meas. best 9.82

EC50 1 meas. best 9.36

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Gastrin/cholecystokinin type B receptor CHEMBL298	IC50	9.82	9.82	0.2	1
Gastrin/cholecystokinin type B receptor CHEMBL298	EC50	9.36	9.36	0.4	1
Cholecystokinin receptor type A CHEMBL1901	IC50	5.4	5.4	3981.1	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Gastrin/cholecystokinin type B receptor	IC50	=	0.1514	nM	9.82	Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell mem...	30624060
Gastrin/cholecystokinin type B receptor	EC50	=	0.4365	nM	9.36	Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 ...	30624060
Cholecystokinin receptor type A	IC50	=	3981.07	nM	5.4	Displacement of [125I]-CCK-8 from human CCK1R expressed in human 1321N1 cell mem...	30624060

Literature References

PubMed	DOI	Target Context	# Activities
30624060	10.1021/acs.jmedchem.8b01558	Cholecystokinin receptor type A	2
30624060	10.1021/acs.jmedchem.8b01558	Gastrin/cholecystokinin type B receptor	2

Data from ChEMBL 36 via Core Engine