Compound Detail
CHEMBL4566722
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Basic Information
| ChEMBL ID | CHEMBL4566722 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZZBKSAODRXUWMW-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
465.7
MW (Da)
5.44
ALogP
6
HBA
2
HBD
62.3
PSA (Ų)
0.59
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EHMT1 CHEMBL6031 | IC50 | 5.9 | 5.9 | 1250.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EHMT1 | IC50 | = | 1250.0 | nM | 5.9 | Inhibition of N-terminal GST tagged human recombinant EHMT1 (794 to 1294 residue... | 31350126 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31350126 | 10.1016/j.bmcl.2019.06.012 | Histone-lysine N-methyltransferase EHMT2 | 1 |
| 31350126 | 10.1016/j.bmcl.2019.06.012 | Histone-lysine N-methyltransferase EHMT1 | 1 |
Data from ChEMBL 36 via Core Engine