Compound Detail
CHEMBL4574756
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CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL4574756 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MQQBPDHRDGGUNE-XUJYPJAKSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
632.8
MW (Da)
0.29
ALogP
7
HBA
8
HBD
204.0
PSA (Ų)
0.09
QED
2
Ro5 Violations
15
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocyte-stimulating hormone receptor CHEMBL4077 | EC50 | 6.4 | 6.4 | 400.0 | 1 |
| Melanocortin receptor 5 CHEMBL4489 | EC50 | 5.77 | 5.77 | 1700.0 | 1 |
| Melanocortin receptor 4 CHEMBL3719 | EC50 | 5.51 | 5.51 | 3100.0 | 1 |
| Melanocortin receptor 3 CHEMBL4774 | EC50 | 5.22 | 5.22 | 6000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocyte-stimulating hormone receptor | EC50 | = | 400.0 | nM | 6.4 | Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells asse... | 32184956 |
| Melanocortin receptor 5 | EC50 | = | 1700.0 | nM | 5.77 | Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells asse... | 32184956 |
| Melanocortin receptor 4 | EC50 | = | 3100.0 | nM | 5.51 | Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells asse... | 32184956 |
| Melanocortin receptor 3 | EC50 | = | 6000.0 | nM | 5.22 | Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells asse... | 32184956 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32184956 | 10.1021/acsmedchemlett.9b00198 | Melanocyte-stimulating hormone receptor | 2 |
| 32184956 | 10.1021/acsmedchemlett.9b00198 | Melanocortin receptor 3 | 2 |
| 32184956 | 10.1021/acsmedchemlett.9b00198 | Melanocortin receptor 4 | 2 |
| 32184956 | 10.1021/acsmedchemlett.9b00198 | Melanocortin receptor 5 | 1 |
Data from ChEMBL 36 via Core Engine