Compound Detail
CHEMBL457481
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O=C(NCCC(c1ccccc1)c1ccccc1)[C@H]1O[C@@H](n2cnc3c(NCc4cccc(I)c4)nc(Cl)nc32)[C@H](O)[C@@H]1O
Basic Information
| ChEMBL ID | CHEMBL457481 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FMNMXTAVNBOPNU-OVDFTCDZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
725.0
MW (Da)
4.65
ALogP
9
HBA
4
HBD
134.4
PSA (Ų)
0.12
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adenosine receptor A3 CHEMBL256 | Ki | 6.46 | 6.46 | 346.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adenosine receptor A3 | Ki | = | 346.74 | nM | 6.46 | Displacement of [125I]I-AB-MEAC from human adenosine A3 receptor expressed in CH... | 18973967 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18973967 | 10.1016/j.ejmech.2008.09.022 | Adenosine receptor A3 | 1 |
Data from ChEMBL 36 via Core Engine