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Compound Detail

CHEMBL458302

NINGNANMYCIN
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CNCC(=O)N[C@@H](CO)C(=O)N[C@H]1[C@H](O)[C@@H](O)[C@H](n2ccc(N)nc2=O)O[C@@H]1C(N)=O

Basic Information

ChEMBL ID CHEMBL458302
Name NINGNANMYCIN
Phase Preclinical
Structure Type MOL
InChI Key AMNAZJFEONUVTD-KEWDHRJRSA-N
1
Targets
5
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

443.4
MW (Da)
-5.89
ALogP
12
HBA
8
HBD
244.2
PSA (Ų)
0.19
QED
2
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C16H25N7O8
MW 443.42
Aromatic Rings 1
Heavy Atoms 31
NP-Likeness 0.80

Activity Summary

IC50 3 meas. best 4.38
EC50 2 meas.

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Tobacco mosaic virus
CHEMBL613818
IC50 4.38 4.34 42200.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25798528 10.1021/np501057f Tobacco mosaic virus 10
18183949 10.1021/jf072394k Tobacco mosaic virus 10
23320928 10.1021/jf304905k Tobacco mosaic virus 8
23078294 10.1021/np300395m Tobacco mosaic virus 8
22500574 10.1021/jf205362d Tobacco mosaic virus 8
22662864 10.1021/jf3013376 Tobacco mosaic virus 8
19586051 10.1021/jf901632j Tobacco mosaic virus 8
23035814 10.1021/jf303550a Tobacco mosaic virus 8
18547045 10.1021/jf800405m Tobacco mosaic virus 8
18939848 10.1021/jf802489e Tobacco mosaic virus 8
20000413 10.1021/jf902543r Tobacco mosaic virus 8
21058739 10.1021/jf103440s Tobacco mosaic virus 6
19199594 10.1021/jf803215t Tobacco mosaic virus 6
20050684 10.1021/jf903434h Tobacco mosaic virus 6
23368966 10.1021/np300727f Tobacco mosaic virus 3
33421712 10.1016/j.ejmech.2020.113102 Tobacco mosaic virus 3
18178446 10.1016/j.bmc.2007.12.035 Tobacco mosaic virus 3
34479038 10.1016/j.ejmech.2021.113815 Tobacco mosaic virus 3
20000408 10.1021/jf902861m Tobacco mosaic virus 3
18945621 10.1016/j.bmc.2008.09.070 Tobacco mosaic virus 3

Data from ChEMBL 36 via Core Engine