Compound Detail
CHEMBL4583543
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Basic Information
| ChEMBL ID | CHEMBL4583543 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MWHQQWNHUURCGY-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
4
PK Parameters
7
Publications
0
Known Names
Molecular Properties
276.4
MW (Da)
3.25
ALogP
4
HBA
1
HBD
51.2
PSA (Ų)
0.82
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein Tat CHEMBL4011 | EC50 | 4.62 | 4.58 | 24000.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 175.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 815.0 | mL.min-1.g-1 | Mus musculus |
| T1/2 | 0.1667 | hr | Homo sapiens |
| T1/2 | 0.03333 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein Tat | EC50 | = | 24000.0 | nM | 4.62 | Activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells harborin... | 30973727 |
| Protein Tat | EC50 | = | 29000.0 | nM | 4.54 | Activation of Tat-mediated HIV1 transcription in HEK293-FlpIn.RV cells harboring... | 30973727 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30973727 | 10.1021/acs.jmedchem.9b00462 | Protein Tat | 13 |
| 30973727 | 10.1021/acs.jmedchem.9b00462 | HEK293 | 5 |
| 30973727 | 10.1021/acs.jmedchem.9b00462 | ADMET | 4 |
| 30973727 | 10.1021/acs.jmedchem.9b00462 | No relevant target | 2 |
| 30973727 | 10.1021/acs.jmedchem.9b00462 | Bromodomain-containing protein 4 | 2 |
| 30973727 | 10.1021/acs.jmedchem.9b00462 | HepG2 | 1 |
| 30973727 | 10.1021/acs.jmedchem.9b00462 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine