Compound Detail
CHEMBL4588267
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C[C@H](c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4c(O)cccc4c23)cc1)N(C)C
Basic Information
| ChEMBL ID | CHEMBL4588267 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YKFJBOIRINHSJC-GFCCVEGCSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
408.9
MW (Da)
5.04
ALogP
4
HBA
3
HBD
76.6
PSA (Ų)
0.42
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| A549 CHEMBL392 | IC50 | 6.29 | 6.29 | 515.6 | 1 |
| Lymphokine-activated killer T-cell-originated protein kinase CHEMBL4896 | IC50 | 5.61 | 5.61 | 2440.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| A549 | IC50 | = | 515.6 | nM | 6.29 | Antiproliferative activity against human A549 cells after 72 hrs by MTT assay | 30453248 |
| Lymphokine-activated killer T-cell-originated protein kinase | IC50 | = | 2440.0 | nM | 5.61 | Inhibition of human TOPK using MBP as substrate after 2 hrs in presence of [gamm... | 30453248 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30453248 | 10.1016/j.ejmech.2018.11.007 | Lymphokine-activated killer T-cell-originated protein kinase | 1 |
| 30453248 | 10.1016/j.ejmech.2018.11.007 | A549 | 1 |
| 30453248 | 10.1016/j.ejmech.2018.11.007 | HCT-116 | 1 |
| 30453248 | 10.1016/j.ejmech.2018.11.007 | HCT-15 | 1 |
Data from ChEMBL 36 via Core Engine