Compound Detail
CHEMBL4590631
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Basic Information
| ChEMBL ID | CHEMBL4590631 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SPTCEOOBTAIXFR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
291.4
MW (Da)
3.92
ALogP
3
HBA
1
HBD
43.8
PSA (Ų)
0.79
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acid-sensing ion channel 2 CHEMBL3232695 | IC50 | 5.06 | 5.06 | 8800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acid-sensing ion channel 2 | IC50 | = | 8800.0 | nM | 5.06 | Inhibition of pH 5.5-stimulated mouse ASIC2a homomer expressed in CHOK1 cells as... | 30996808 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30996808 | 10.1021/acsmedchemlett.8b00591 | Acid-sensing ion channel 1 | 1 |
| 30996808 | 10.1021/acsmedchemlett.8b00591 | Acid-sensing ion channel 2 | 1 |
| 30996808 | 10.1021/acsmedchemlett.8b00591 | Acid-sensing ion channel 1/2 | 1 |
Data from ChEMBL 36 via Core Engine