Compound Detail
CHEMBL4591220
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4591220 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SWEWMDUQEJZUMC-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
289.2
MW (Da)
1.45
ALogP
4
HBA
4
HBD
127.7
PSA (Ų)
0.68
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polymerase acidic protein CHEMBL1169598 | IC50 | 9.6 | 8.12 | 0.3 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polymerase acidic protein | IC50 | = | 0.2512 | nM | 9.6 | Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endon... | 31536340 |
| Polymerase acidic protein | IC50 | = | 230.0 | nM | 6.64 | Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endon... | 31536340 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31536340 | 10.1021/acs.jmedchem.9b00747 | Polymerase acidic protein | 3 |
Data from ChEMBL 36 via Core Engine