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Compound Detail

CHEMBL459252

TOMENTODIPLACONE
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C=C(C)C(O)CC/C(C)=C/Cc1c(O)cc2c(c1O)C(=O)C[C@@H](c1ccc(O)c(OC)c1)O2

Basic Information

ChEMBL ID CHEMBL459252
Name TOMENTODIPLACONE
Phase Preclinical
Structure Type MOL
InChI Key JDLZAZIAVULNSS-SGJLQWKXSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
15
Publications
0
Known Names

Molecular Properties

454.5
MW (Da)
4.72
ALogP
7
HBA
4
HBD
116.5
PSA (Ų)
0.43
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C26H30O7
MW 454.52
Aromatic Rings 2
Heavy Atoms 33
NP-Likeness 2.43

Literature References

PubMed DOI Target Context # Activities
18293924 10.1021/np070446u Bacillus cereus 1
18293924 10.1021/np070446u Listeria monocytogenes 1
18293924 10.1021/np070446u Staphylococcus aureus 1
18293924 10.1021/np070446u Staphylococcus epidermidis 1
18293924 10.1021/np070446u Escherichia coli 1
18293924 10.1021/np070446u Pseudomonas aeruginosa 1
18293924 10.1021/np070446u Salmonella enteritidis 1
18293924 10.1021/np070446u Candida albicans 1
20192247 10.1021/np900681y MCF7 1
20192247 10.1021/np900681y CCRF-CEM 1
20192247 10.1021/np900681y RPMI-8226 1
20192247 10.1021/np900681y U-266 1
20192247 10.1021/np900681y HeLa 1
20192247 10.1021/np900681y BJ 1
20192247 10.1021/np900681y THP-1 1

Data from ChEMBL 36 via Core Engine