Compound Detail
CHEMBL4594278
GEFAPIXANT CITRATE 💊 Approved Drug
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💊 Approved Drug
COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1S(N)(=O)=O.O=C(O)CC(O)(CC(=O)O)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL4594278 |
| Name | GEFAPIXANT CITRATE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | AIJVJYUOMCRFOE-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL3716057 |
| Active Moiety | CHEMBL3716057 |
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
0
Publications
7
Known Names
2
Indications
1
Mechanisms
Molecular Properties
353.4
MW (Da)
1.21
ALogP
8
HBA
3
HBD
156.4
PSA (Ų)
0.72
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2023 |
| Availability | Unknown |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| P2X purinoceptor 3 antagonist | ANTAGONIST | P2X purinoceptor 3 | ✓ | ✓ |
Indications
Chronic Cough Cough
Data from ChEMBL 36 via Core Engine