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Compound Detail

CHEMBL4594287

ENSIFENTRINE
💊 Approved Drug
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💊 Approved Drug
COc1cc2c(cc1OC)-c1c/c(=N\c3c(C)cc(C)cc3C)n(CCNC(N)=O)c(=O)n1CC2
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4594287
Name ENSIFENTRINE
Phase Approved
Structure Type MOL
InChI Key CSOBIBXVIYAXFM-BYNJWEBRSA-N
Therapeutic ✓ Yes

Known Names

Ensifentrina Ensifentrine Ls-193,855 Ls-193855 Ohtuvayre RPL-554 RPL554
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
1
Publications
7
Known Names
4
Indications
2
Mechanisms

Molecular Properties

477.6
MW (Da)
2.72
ALogP
7
HBA
2
HBD
112.9
PSA (Ų)
0.57
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2024
Availability Prescription
Chirality Achiral

Routes of Administration

Topical
USAN Stem -fentrine
USAN Year 2019

Extended Properties

Molecular Formula C26H31N5O4
MW 477.57
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -0.58

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Phosphodiesterase 4 inhibitor INHIBITOR Phosphodiesterase 4 ✓ ✓
Phosphodiesterase 3 inhibitor INHIBITOR Phosphodiesterase 3 ✓ ✓

Indications

Pulmonary Disease, Chronic Obstructive Asthma Cystic Fibrosis Severe Acute Respiratory Syndrome

Literature References

PubMed DOI Target Context # Activities
32255344 10.1021/acs.jmedchem.9b02170 Unchecked 1

Data from ChEMBL 36 via Core Engine