Compound Detail
CHEMBL4594418
SURLORIAN 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL4594418 |
| Name | SURLORIAN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | JIGDAUOKKYKRKO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
6
Known Names
1
Indications
Molecular Properties
329.4
MW (Da)
3.50
ALogP
4
HBA
1
HBD
49.8
PSA (Ų)
0.93
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Polymorphic Catecholaminergic Ventricular Tachycardia
Activity Summary
EC50 1 meas. best 4.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 CHEMBL4523144 | EC50 | 4.46 | 4.46 | 34300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | EC50 | = | 34300.0 | nM | 4.46 | Activation of SERCA2a in mouse HL-1 cells assessed as increase in caffeine-induc... | 37991191 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37991191 | 10.1021/acs.jmedchem.3c01235 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | 4 |
| 37991191 | 10.1021/acs.jmedchem.3c01235 | ADMET | 1 |
| 37991191 | 10.1021/acs.jmedchem.3c01235 | Unchecked | 1 |
| 37991191 | 10.1021/acs.jmedchem.3c01235 | Ryanodine receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine