Compound Detail
CHEMBL4594422
LB-102 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL4594422 |
| Name | LB-102 |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | NXKXZXNNWRYXRE-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
3
Known Names
1
Indications
Molecular Properties
383.5
MW (Da)
1.74
ALogP
6
HBA
2
HBD
87.7
PSA (Ų)
0.71
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Indications
Schizophrenia
Activity Summary
IC50 4 meas. best 8.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL217 | IC50 | 8.09 | 8.07 | 8.2 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | IC50 | = | 8.2 | nM | 8.09 | Binding of Compound 102 to Dopamine D2 Receptors (Membrane Preparation): The abi... | - |
| D(2) dopamine receptor | IC50 | = | 8.2 | nM | 8.09 | Binding of Compound 102 to Dopamine D2 Receptors (Membrane Preparation): The abi... | - |
| D(2) dopamine receptor | IC50 | = | 8.9 | nM | 8.05 | Dopamine D2 Receptors (Cell-Based Assay): The ability of Compound 102 to bind do... | - |
| D(2) dopamine receptor | IC50 | = | 8.9 | nM | 8.05 | Binding of Compound 102 to Dopamine D2 Receptors (Cell-Based Assay): The ability... | - |
Data from ChEMBL 36 via Core Engine