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Compound Detail

CHEMBL459822

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O=c1cc(-c2ccc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(O)c2)oc2cc(O)cc(O)c12

Basic Information

ChEMBL ID CHEMBL459822
Phase Preclinical
Structure Type MOL
InChI Key UHNXUSWGOJMEFO-QNDFHXLGSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

448.4
MW (Da)
-0.24
ALogP
11
HBA
7
HBD
190.3
PSA (Ų)
0.28
QED
2
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C21H20O11
MW 448.38
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness 2.01

Literature References

PubMed DOI Target Context # Activities
25987378 10.1016/j.bmcl.2015.04.052 Unchecked 4
11473417 10.1021/np0100845 NON-PROTEIN TARGET 3
25987378 10.1016/j.bmcl.2015.04.052 ADMET 3
25987378 10.1016/j.bmcl.2015.04.052 Tyrosinase 2
7623048 10.1021/np50119a013 Tyrosinase 1
19944611 10.1016/j.bmc.2009.11.015 NON-PROTEIN TARGET 1
25987378 10.1016/j.bmcl.2015.04.052 Plasminogen 1
25999202 10.1016/j.bmc.2015.04.053 Unchecked 1

Data from ChEMBL 36 via Core Engine