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Compound Detail

CHEMBL460312

FKGK11
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O=C(CCCCc1ccccc1)C(F)(F)C(F)(F)F
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL460312
Name FKGK11
Phase Preclinical
Structure Type MOL
InChI Key ROPVXAWEVYWEQY-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

280.2
MW (Da)
4.17
ALogP
1
HBA
0
HBD
17.1
PSA (Ų)
0.56
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H13F5O
MW 280.24
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness -0.22

Literature References

PubMed DOI Target Context # Activities
19053783 10.1021/jm800649q 85/88 kDa calcium-independent phospholipase A2 2
20369880 10.1021/jm901872v 85/88 kDa calcium-independent phospholipase A2 2
30798607 10.1021/acs.jmedchem.8b01216 85/88 kDa calcium-independent phospholipase A2 2
19053783 10.1021/jm800649q Cytosolic phospholipase A2 1
19053783 10.1021/jm800649q Phospholipase A2 group V 1
20369880 10.1021/jm901872v Phospholipase A2 group V 1
20369880 10.1021/jm901872v Cytosolic phospholipase A2 1
27234891 10.1016/j.bmc.2016.05.017 Unchecked 1
30798607 10.1021/acs.jmedchem.8b01216 Cytosolic phospholipase A2 1
30798607 10.1021/acs.jmedchem.8b01216 Unchecked 1

Data from ChEMBL 36 via Core Engine