Compound Detail
CHEMBL4636577
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4636577 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KHQBQZAYKBKWTN-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
396.6
MW (Da)
4.92
ALogP
3
HBA
1
HBD
53.2
PSA (Ų)
0.68
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Complement factor B CHEMBL5731 | IC50 | 8.89 | 8.89 | 1.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Complement factor B | IC50 | = | 1.3 | nM | 8.89 | Human Complement Factor B TR-FRET Assay: CVF-Bb complex prepared from purified c... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32073845 | 10.1021/acs.jmedchem.9b01870 | Complement factor B | 1 |
Data from ChEMBL 36 via Core Engine