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Compound Detail

CHEMBL464548

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CCOP(=O)(Cc1ccc(NC(=O)CCCNC(=O)[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)cc1)OCC

Basic Information

ChEMBL ID CHEMBL464548
Phase Preclinical
Structure Type MOL
InChI Key NLEXSAYIQIVTAR-UGCAPWQASA-N
0
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

591.6
MW (Da)
1.33
ALogP
13
HBA
5
HBD
213.0
PSA (Ų)
0.14
QED
2
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H34N7O8P
MW 591.56
Aromatic Rings 3
Heavy Atoms 41
NP-Likeness -0.16

Activity Summary

Ki 3 meas.

Literature References

PubMed DOI Target Context # Activities
18630897 10.1021/jm800175e Ectonucleoside triphosphate diphosphohydrolase 8 1
18630897 10.1021/jm800175e Ectonucleoside triphosphate diphosphohydrolase 3 1
18630897 10.1021/jm800175e Ectonucleoside triphosphate diphosphohydrolase 2 1
18630897 10.1021/jm800175e Ectonucleoside triphosphate diphosphohydrolase 1 1
18630897 10.1021/jm800175e P2Y purinoceptor 2 1
18630897 10.1021/jm800175e P2Y purinoceptor 4 1
18630897 10.1021/jm800175e P2Y purinoceptor 6 1

Data from ChEMBL 36 via Core Engine