Compound Detail
CHEMBL464620
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Basic Information
| ChEMBL ID | CHEMBL464620 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IEPRETGMTYNEJR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
328.8
MW (Da)
2.72
ALogP
5
HBA
3
HBD
95.6
PSA (Ų)
0.67
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 5000.0 | nM | 5.3 | Inhibition of VEGFR2 by HTRF assay in presence of 2 uM ATP | 19188066 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19188066 | 10.1016/j.bmcl.2009.01.046 | Vascular endothelial growth factor receptor 2 | 2 |
Data from ChEMBL 36 via Core Engine