Compound Detail
CHEMBL46486
TETRAMETHYLAMMONIUM ION Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL46486 |
| Name | TETRAMETHYLAMMONIUM ION |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QEMXHQIAXOOASZ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
74.2
MW (Da)
0.32
ALogP
0
HBA
0
HBD
0.0
PSA (Ų)
0.36
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuronal acetylcholine receptor; alpha4/beta2 CHEMBL1907589 | Ki | 7.62 | 7.62 | 24.0 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 CHEMBL2492 | Ki | 5.64 | 5.64 | 2300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuronal acetylcholine receptor; alpha4/beta2 | Ki | = | 24.0 | nM | 7.62 | Binding affinity at heteropentameric Nicotinic acetylcholine receptor alpha4-bet... | 10447950 |
| Neuronal acetylcholine receptor subunit alpha-7 | Ki | = | 2300.0 | nM | 5.64 | Binding affinity at homopentameric Nicotinic acetylcholine receptor alpha-7 subt... | 10447950 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 6094812 | 10.1021/jm00378a021 | ADMET | 1 |
| 10447950 | 10.1021/jm990093z | Neuronal acetylcholine receptor; alpha4/beta2 | 1 |
| 10447950 | 10.1021/jm990093z | Neuronal acetylcholine receptor subunit alpha-7 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine