Compound Detail
CHEMBL4650216
DARIDOREXANT HYDROCHLORIDE 💊 Approved Drug
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💊 Approved Drug
COc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@]2(C)c2nc3c(C)c(Cl)ccc3[nH]2)c1.Cl
Basic Information
| ChEMBL ID | CHEMBL4650216 |
| Name | DARIDOREXANT HYDROCHLORIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | HJVGDXBEMFHGKI-BQAIUKQQSA-N |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL4297590 |
| Active Moiety | CHEMBL4297590 |
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
0
Publications
5
Known Names
1
Indications
2
Mechanisms
Molecular Properties
450.9
MW (Da)
4.27
ALogP
6
HBA
1
HBD
88.9
PSA (Ų)
0.50
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2022 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Orexin receptor 1 antagonist | ANTAGONIST | Orexin/Hypocretin receptor type 1 | ✓ | ✓ |
| Orexin receptor 2 antagonist | ANTAGONIST | Orexin receptor type 2 | ✓ | ✓ |
Indications
Sleep Initiation and Maintenance Disorders
Data from ChEMBL 36 via Core Engine