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Compound Detail

CHEMBL4650220

ZAVEGEPANT HYDROCHLORIDE
💊 Approved Drug
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💊 Approved Drug
Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCN(C3CCN(C)CC3)CC2)cc2cn[nH]c12.Cl
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4650220
Name ZAVEGEPANT HYDROCHLORIDE
Phase Approved
Structure Type MOL
InChI Key VQDUWCSSPSOSNA-RYWNGCACSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL2397415
Active Moiety CHEMBL2397415

Known Names

BHV-3500 hydrochloride BMS-742413 hydrochloride BMS-742413-03 Zavegepant hydrochloride Zavzpret
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
0
Publications
5
Known Names
1
Indications
1
Mechanisms

Molecular Properties

638.8
MW (Da)
3.45
ALogP
6
HBA
3
HBD
120.7
PSA (Ų)
0.30
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2023
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Topical
USAN Stem -gepant
USAN Year 2020

Extended Properties

Molecular Formula C36H47ClN8O3
MW 675.28
Aromatic Rings 4
Heavy Atoms 47
NP-Likeness -1.11

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Calcitonin gene-related peptide type 1 receptor antagonist ANTAGONIST Calcitonin gene-related peptide type 1 receptor ✓ ✓

Indications

Migraine Disorders

Data from ChEMBL 36 via Core Engine