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Compound Detail

CHEMBL4650339

DALOSIRVAT
🧪 Phase II
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🧪 Phase II
O=C(CCC(=O)c1ccc2c(c1)OCCO2)c1ccccc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4650339
Name DALOSIRVAT
Phase Phase II
Structure Type MOL
InChI Key AOCDRSSVFUCURK-UHFFFAOYSA-N

Known Names

Dalosirvat SM-04554 Sm04554
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
3
Known Names
2
Indications

Molecular Properties

296.3
MW (Da)
3.30
ALogP
4
HBA
0
HBD
52.6
PSA (Ų)
0.79
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral
USAN Stem -sirvat
USAN Year 2021

Extended Properties

Molecular Formula C18H16O4
MW 296.32
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -0.53

Indications

Alopecia Alopecia

Activity Summary

IC50 1 meas. best 7.54

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Catenin beta-1
CHEMBL5866
 IC50 7.54 7.54 28.5 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Catenin beta-1 IC50 = 28.5 nM 7.54 Wnt activity assay: Compounds that enhance the Wnt activity, or Activators, were... -

Data from ChEMBL 36 via Core Engine