Compound Detail
CHEMBL46567
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Basic Information
| ChEMBL ID | CHEMBL46567 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CBKOOGJFEQBENF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
403.5
MW (Da)
5.09
ALogP
5
HBA
0
HBD
47.8
PSA (Ų)
0.47
QED
1
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; alpha-3/beta-3/gamma-2 CHEMBL2094120 | Ki | 8.52 | 8.52 | 3.0 | 1 |
| GABA-A receptor; alpha-1/beta-3/gamma-2 CHEMBL2094121 | Ki | 8.3 | 8.3 | 5.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; alpha-3/beta-3/gamma-2 | Ki | = | 3.0 | nM | 8.52 | Binding affinity at human recombinant gamma-aminobutyric-acid A receptor alpha-3... | 15026049 |
| GABA-A receptor; alpha-1/beta-3/gamma-2 | Ki | = | 5.0 | nM | 8.3 | Binding affinity at human recombinant gamma-aminobutyric-acid A receptor alpha-1... | 15026049 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15026049 | 10.1016/j.bmcl.2004.01.057 | GABA-A receptor; alpha-1/beta-3/gamma-2 | 1 |
| 15026049 | 10.1016/j.bmcl.2004.01.057 | GABA-A receptor; alpha-3/beta-3/gamma-2 | 1 |
| 15026049 | 10.1016/j.bmcl.2004.01.057 | Gamma-aminobutyric acid receptor subunit alpha-1 | 1 |
| 15026049 | 10.1016/j.bmcl.2004.01.057 | Gamma-aminobutyric acid receptor subunit alpha-3 | 1 |
Data from ChEMBL 36 via Core Engine