Compound Detail
CHEMBL468255
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Basic Information
| ChEMBL ID | CHEMBL468255 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HMNAGLOPAPINKX-BJMVGYQFSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
267.7
MW (Da)
4.11
ALogP
2
HBA
0
HBD
40.9
PSA (Ų)
0.62
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.98
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 4.98 | 4.98 | 10500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 10500.0 | nM | 4.98 | Antimalarial activity after 24 hrs against chloroquine-resistant Plasmodium falc... | 19250824 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19250824 | 10.1016/j.bmcl.2009.02.042 | Plasmodium falciparum | 2 |
| 19250824 | 10.1016/j.bmcl.2009.02.042 | Protein kinase Pfmrk | 1 |
| 19250824 | 10.1016/j.bmcl.2009.02.042 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine