Compound Detail
CHEMBL471498
MITIGLINIDE 🧪 Phase III
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL471498 |
| Name | MITIGLINIDE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | WPGGHFDDFPHPOB-BBWFWOEESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
2
Known Names
2
Indications
1
Mechanisms
Molecular Properties
315.4
MW (Da)
2.97
ALogP
2
HBA
1
HBD
57.6
PSA (Ų)
0.91
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Sulfonylurea receptor 1, Kir6.2 blocker | BLOCKER | Sulfonylurea receptor 1, Kir6.2 | ✓ | ✓ |
Indications
Diabetes Mellitus Diabetes Mellitus, Type 2
ATC Classification
A10BX08
mitiglinide
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: DRUGS USED IN DIABETES
Activity Summary
EC50 1 meas. best 6.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 6.15 | 6.15 | 708.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 708.0 | nM | 6.15 | Increase in insulin releasing activity in Syrian golden hamster HIT-T15 cells af... | 18191001 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18191001 | 10.1016/j.ejmech.2007.11.018 | Rattus norvegicus | 5 |
| 18191001 | 10.1016/j.ejmech.2007.11.018 | Unchecked | 4 |
| 20014752 | 10.1021/tx900326k | Hepatotoxicity | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 1A | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-2A adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2B | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Gamma-aminobutyric acid receptor subunit alpha-1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Progesterone receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2A | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 33369426 | 10.1021/acs.jmedchem.0c01762 | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Beta-2 adrenergic receptor | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Sodium-dependent dopamine transporter | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Neuronal acetylcholine receptor subunit alpha-4 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Voltage-dependent L-type calcium channel subunit alpha-1C | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Kappa-type opioid receptor | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Adenosine receptor A3 | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M1 | 1 |
Data from ChEMBL 36 via Core Engine