Compound Detail
CHEMBL472723
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COc1ccc(C2C(C#N)=C(N)OC3=C2C(=O)CC(c2ccco2)C3)cc1OC(=O)N1CCOCC1
Basic Information
| ChEMBL ID | CHEMBL472723 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RIOQOZJDLKYMQC-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
491.5
MW (Da)
3.33
ALogP
9
HBA
1
HBD
137.2
PSA (Ų)
0.68
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Excitatory amino acid transporter 1 CHEMBL3085 | IC50 | 4.0 | 4.0 | 100000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Excitatory amino acid transporter 1 | IC50 | = | 100000.0 | nM | 4.0 | Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells | 19161278 |
| Excitatory amino acid transporter 1 | IC50 | = | 100000.0 | nM | 4.0 | Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells | 19161278 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19161278 | 10.1021/jm8013458 | Excitatory amino acid transporter 1 | 2 |
| 19161278 | 10.1021/jm8013458 | Excitatory amino acid transporter 2 | 2 |
| 19161278 | 10.1021/jm8013458 | Excitatory amino acid transporter 3 | 2 |
Data from ChEMBL 36 via Core Engine