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Compound Detail

CHEMBL4739914

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COc1cc(OC)c(Cl)c(COc2cnc(Nc3c(C)cccc3NC(=O)CC#N)nc2)c1Cl
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4739914
Phase Preclinical
Structure Type MOL
InChI Key WDTLFYYWHXCUIU-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

502.4
MW (Da)
5.28
ALogP
8
HBA
2
HBD
118.4
PSA (Ų)
0.41
QED
2
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H21Cl2N5O4
MW 502.36
Aromatic Rings 3
Heavy Atoms 34
NP-Likeness -1.07

Literature References

PubMed DOI Target Context # Activities
33859803 10.1021/acsmedchemlett.1c00052 Fibroblast growth factor receptor 4 1
33859803 10.1021/acsmedchemlett.1c00052 Fibroblast growth factor receptor 1 1
33859803 10.1021/acsmedchemlett.1c00052 Fibroblast growth factor receptor 2 1
33859803 10.1021/acsmedchemlett.1c00052 Fibroblast growth factor receptor 3 1

Data from ChEMBL 36 via Core Engine