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Compound Detail

CHEMBL4739954

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O=C(O)c1cccc(-c2cnc(-c3ccccc3F)o2)c1

Basic Information

ChEMBL ID CHEMBL4739954
Phase Preclinical
Structure Type MOL
InChI Key JJDOTOIQSCTJRY-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
2
PK Parameters
3
Publications
0
Known Names

Molecular Properties

283.3
MW (Da)
3.85
ALogP
3
HBA
1
HBD
63.3
PSA (Ų)
0.79
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H10FNO3
MW 283.26
Aromatic Rings 3
Heavy Atoms 21
NP-Likeness -1.14

Activity Summary

EC50 1 meas. best 5.59

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 5.59 5.59 2550.0 1

Pharmacokinetic Data

Parameter Value Units Species
T1/2 3.455 hr Homo sapiens
T1/2 2.22 hr Mus musculus

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked EC50 = 2550.0 nM 5.59 Activation of NF-KappaB (unknown origin) expressed in SH-SY5Y cells co-transfect... 33139114

Literature References

PubMed DOI Target Context # Activities
33139114 10.1016/j.ejmech.2020.112952 Unchecked 2
33139114 10.1016/j.ejmech.2020.112952 ADMET 2
33139114 10.1016/j.ejmech.2020.112952 No relevant target 1

Data from ChEMBL 36 via Core Engine