Compound Detail
CHEMBL4741377
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Basic Information
| ChEMBL ID | CHEMBL4741377 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JYKFJDOJASDJSM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
235.3
MW (Da)
1.35
ALogP
4
HBA
2
HBD
85.1
PSA (Ų)
0.82
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | IC50 | 4.8 | 4.8 | 15700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | = | 15700.0 | nM | 4.8 | Inhibition of DYRK1A (unknown origin) by [33P]-ATP filter binding kinase assay | 27736065 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27736065 | 10.1021/acs.jmedchem.6b01086 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2 |
Data from ChEMBL 36 via Core Engine