Compound Detail
CHEMBL474701
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL474701 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TYRWITFDDYPZEI-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
376.5
MW (Da)
3.61
ALogP
7
HBA
0
HBD
79.3
PSA (Ų)
0.65
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.73
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL4649 | IC50 | 8.73 | 8.73 | 1.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | IC50 | = | 1.88 | nM | 8.73 | Displacement of [125I]Tyr0-ovine CRF from CRF1 receptor in rat cortical membrane... | 19361210 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19361210 | 10.1021/jm9000242 | Corticotropin-releasing factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine