Compound Detail
CHEMBL4749169
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Basic Information
| ChEMBL ID | CHEMBL4749169 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OVIFVLVJLJPJEZ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
457.6
MW (Da)
3.81
ALogP
7
HBA
2
HBD
83.3
PSA (Ų)
0.42
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 2 CHEMBL1804 | EC50 | 7.4 | 7.39 | 39.8 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 2 | EC50 | = | 39.81 | nM | 7.4 | Agonist activity at human SST2 expressed in CHOK1 cells assessed as inhibition o... | 32805408 |
| Somatostatin receptor type 2 | EC50 | = | 42.0 | nM | 7.38 | Agonist activity at human SST2 expressed in CHOK1 cells assessed as inhibition o... | 32805408 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32805408 | 10.1016/j.bmcl.2020.127496 | Somatostatin receptor type 2 | 2 |
Data from ChEMBL 36 via Core Engine