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Compound Detail

CHEMBL4750816

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COc1cc(OC)c(Cl)c(COc2cnc(Nc3c(C)cccc3NC#N)nc2)c1Cl
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4750816
Phase Preclinical
Structure Type MOL
InChI Key TYZARYXVJAAWDV-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

460.3
MW (Da)
5.32
ALogP
8
HBA
2
HBD
101.3
PSA (Ų)
0.34
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H19Cl2N5O3
MW 460.32
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -0.85

Literature References

PubMed DOI Target Context # Activities
33859803 10.1021/acsmedchemlett.1c00052 Fibroblast growth factor receptor 4 1
33859803 10.1021/acsmedchemlett.1c00052 Fibroblast growth factor receptor 1 1
33859803 10.1021/acsmedchemlett.1c00052 Fibroblast growth factor receptor 2 1
33859803 10.1021/acsmedchemlett.1c00052 Fibroblast growth factor receptor 3 1

Data from ChEMBL 36 via Core Engine