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Compound Detail

CHEMBL4753332

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CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC

Basic Information

ChEMBL ID CHEMBL4753332
Phase Preclinical
Structure Type MOL
InChI Key UTUWPAUJZCCHLM-MAOURQADSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
13
Publications
0
Known Names

Molecular Properties

783.8
MW (Da)
2.55
ALogP
16
HBA
5
HBD
239.8
PSA (Ų)
0.21
QED
2
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C40H49NO15
MW 783.82
Aromatic Rings 2
Heavy Atoms 56
NP-Likeness 1.56

Activity Summary

IC50 1 meas. best 5.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
K562
CHEMBL385
IC50 5.52 5.52 3035.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
K562 IC50 = 3035.0 nM 5.52 Cytotoxicity in human K562 cells assessed as reduction in cell viability incubat... 33064004

Literature References

Data from ChEMBL 36 via Core Engine