Compound Detail
CHEMBL4755160
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Basic Information
| ChEMBL ID | CHEMBL4755160 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ABNCKEFQRBDVEW-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
313.1
MW (Da)
2.09
ALogP
5
HBA
4
HBD
98.0
PSA (Ų)
0.56
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.16 | 5.9533 | 700.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 700.0 | nM | 6.16 | Inhibition of bovine lung sGC assessed as reduction in GMP level incubated for 2... | 33290062 |
| Unchecked | IC50 | = | 700.0 | nM | 6.16 | Inhibition of bovine lung sGC assessed as reduction in GMP level incubated for 2... | 33290062 |
| Unchecked | IC50 | = | 2900.0 | nM | 5.54 | Inhibition of bovine lung sGC assessed as reduction in GMP level incubated for 2... | 33290062 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33290062 | 10.1021/acs.jnatprod.0c00854 | Unchecked | 9 |
Data from ChEMBL 36 via Core Engine