Compound Detail
CHEMBL4755436
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Basic Information
| ChEMBL ID | CHEMBL4755436 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SUIARNGBSSSKCL-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
422.8
MW (Da)
3.77
ALogP
6
HBA
2
HBD
97.2
PSA (Ų)
0.51
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 10.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 CHEMBL2971 | Ki | 10.05 | 9.335 | 0.1 | 2 |
| Tyrosine-protein kinase JAK1 CHEMBL2835 | Ki | 9.39 | 8.75 | 0.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 | Ki | = | 0.09 | nM | 10.05 | JAK Enzyme Assay: The activity of the isolated recombinant JAK1 and JAK2 kinase ... | - |
| Tyrosine-protein kinase JAK1 | Ki | = | 0.41 | nM | 9.39 | JAK Enzyme Assay: The activity of the isolated recombinant JAK1 and JAK2 kinase ... | - |
| Tyrosine-protein kinase JAK2 | Ki | = | 2.4 | nM | 8.62 | Inhibition of recombinant human JAK2 (812 to 1132 residues) expressed in insect ... | 30981576 |
| Tyrosine-protein kinase JAK1 | Ki | = | 7.8 | nM | 8.11 | Inhibition of recombinant human JAK1 (854 to 1154 residues) expressed in insect ... | 30981576 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30981576 | 10.1016/j.bmcl.2019.04.008 | Tyrosine-protein kinase JAK1 | 1 |
| 30981576 | 10.1016/j.bmcl.2019.04.008 | Janus Kinase (JAK) | 1 |
| 30981576 | 10.1016/j.bmcl.2019.04.008 | Tyrosine-protein kinase JAK2 | 1 |
Data from ChEMBL 36 via Core Engine