Compound Detail
CHEMBL4759868
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Basic Information
| ChEMBL ID | CHEMBL4759868 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MUAOWZOXUPYUNB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
327.4
MW (Da)
3.18
ALogP
5
HBA
3
HBD
71.0
PSA (Ų)
0.58
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone acetyltransferase p300 CHEMBL3784 | IC50 | 6.16 | 6.16 | 690.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone acetyltransferase p300 | IC50 | = | 690.0 | nM | 6.16 | Inhibition of N-terminal His/GST-tagged human p300 HAT (965 to 1810 residues) ex... | 33045661 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33045661 | 10.1016/j.ejmech.2020.112861 | Histone acetyltransferase p300 | 1 |
Data from ChEMBL 36 via Core Engine