Compound Detail
CHEMBL4777598
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Cc1nc(N2CCCC(F)(F)CC2)c(C(=O)Nc2ccnc(S(N)(=O)=O)c2)cc1C(F)(F)F
Basic Information
| ChEMBL ID | CHEMBL4777598 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IFWUDQJJPUXEKC-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
493.5
MW (Da)
3.33
ALogP
6
HBA
2
HBD
118.3
PSA (Ų)
0.63
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium channel protein type 10 subunit alpha CHEMBL5451 | IC50 | 9.3 | 9.3 | 0.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium channel protein type 10 subunit alpha | IC50 | = | 0.5 | nM | 9.3 | Inhibition of human Nav1.8 expressed in HEK293 cells by whole cell patch clamp a... | 33335650 |
| Sodium channel protein type 10 subunit alpha | IC50 | = | 0.5 | nM | 9.3 | Biological Assay: The following buffers were used for the Qube® recordings: Exte... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33335650 | 10.1021/acsmedchemlett.0c00568 | Sodium channel protein type 10 subunit alpha | 1 |
Data from ChEMBL 36 via Core Engine