Compound Detail
CHEMBL4777918
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Basic Information
| ChEMBL ID | CHEMBL4777918 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MWZHPPQRBJHFTB-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
425.3
MW (Da)
4.33
ALogP
5
HBA
1
HBD
72.8
PSA (Ų)
0.53
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | EC50 | 6.55 | 6.55 | 280.0 | 1 |
| Corpus cavernosum CHEMBL4800705 | EC50 | 6.55 | 6.55 | 280.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | EC50 | = | 280.0 | nM | 6.55 | Inhibition of PDE5 in human platelets incubated for 30 mins using cGMP as substr... | 32631538 |
| Corpus cavernosum | EC50 | = | 280.03 | nM | 6.55 | Induction of smooth muscle relaxation in male albino rat corpus-cavernosum asses... | 32631538 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32631538 | 10.1016/j.bmcl.2020.127337 | cGMP-specific 3',5'-cyclic phosphodiesterase | 2 |
| 32631538 | 10.1016/j.bmcl.2020.127337 | Corpus cavernosum | 1 |
Data from ChEMBL 36 via Core Engine