Compound Detail
CHEMBL4780070
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Basic Information
| ChEMBL ID | CHEMBL4780070 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MURNDAWLFYCTAR-UHFFFAOYSA-N |
3
Targets
7
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
421.8
MW (Da)
4.59
ALogP
6
HBA
2
HBD
92.8
PSA (Ų)
0.49
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 6 meas. best 9.77
IC50 1 meas. best 8.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 CHEMBL2971 | Ki | 9.77 | 9.1633 | 0.2 | 3 |
| Tyrosine-protein kinase JAK1 CHEMBL2835 | Ki | 9.29 | 8.4967 | 0.5 | 3 |
| Janus Kinase (JAK) CHEMBL2363062 | IC50 | 8.04 | 8.04 | 9.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 | Ki | = | 0.17 | nM | 9.77 | Inhibition of recombinant human JAK2 (812 to 1132 residues) expressed in insect ... | 30981576 |
| Tyrosine-protein kinase JAK1 | Ki | = | 0.51 | nM | 9.29 | Inhibition of recombinant human JAK1 (854 to 1154 residues) expressed in insect ... | 30981576 |
| Tyrosine-protein kinase JAK2 | Ki | = | 0.96 | nM | 9.02 | JAK Enzyme Assay: The activity of the isolated recombinant JAK1 and JAK2 kinase ... | - |
| Tyrosine-protein kinase JAK2 | Ki | = | 2.02 | nM | 8.7 | JAK Enzyme Assay: The activity of the isolated recombinant JAK1 and JAK2 kinase ... | - |
| Tyrosine-protein kinase JAK1 | Ki | = | 6.55 | nM | 8.18 | JAK Enzyme Assay: The activity of the isolated recombinant JAK1 and JAK2 kinase ... | - |
| Janus Kinase (JAK) | IC50 | = | 9.2 | nM | 8.04 | Inhibition of JAK in human BEAS-2B cells assessed as reduction in IL13-induced S... | 30981576 |
| Tyrosine-protein kinase JAK1 | Ki | = | 9.5 | nM | 8.02 | JAK Enzyme Assay: The activity of the isolated recombinant JAK1 and JAK2 kinase ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30981576 | 10.1016/j.bmcl.2019.04.008 | Tyrosine-protein kinase JAK1 | 1 |
| 30981576 | 10.1016/j.bmcl.2019.04.008 | Janus Kinase (JAK) | 1 |
| 30981576 | 10.1016/j.bmcl.2019.04.008 | Tyrosine-protein kinase JAK2 | 1 |
Data from ChEMBL 36 via Core Engine