Compound Detail
CHEMBL4783828
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Basic Information
| ChEMBL ID | CHEMBL4783828 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VQJLDVNKIIBXFW-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
452.5
MW (Da)
4.15
ALogP
6
HBA
0
HBD
52.3
PSA (Ų)
0.31
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proprotein convertase subtilisin/kexin type 9 CHEMBL2929 | EC50 | 7.06 | 7.06 | 88.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proprotein convertase subtilisin/kexin type 9 | EC50 | = | 88.0 | nM | 7.06 | Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expressi... | 32823006 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32823006 | 10.1016/j.ejmech.2020.112678 | Proprotein convertase subtilisin/kexin type 9 | 1 |
| 32823006 | 10.1016/j.ejmech.2020.112678 | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine