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Compound Detail

CHEMBL4784624

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CCC(=O)c1cccc(C(=O)Nc2ccc(S(=O)(=O)Oc3cccc([N+](=O)[O-])c3)cc2)c1

Basic Information

ChEMBL ID CHEMBL4784624
Phase Preclinical
Structure Type MOL
InChI Key VRTSVHKDABJZIN-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

454.5
MW (Da)
4.21
ALogP
7
HBA
1
HBD
132.7
PSA (Ų)
0.23
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H18N2O7S
MW 454.46
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -1.43

Literature References

PubMed DOI Target Context # Activities
31727469 10.1016/j.ejmech.2019.111789 P2Y purinoceptor 2 2
31727469 10.1016/j.ejmech.2019.111789 Uracil nucleotide/cysteinyl leukotriene receptor 2
31727469 10.1016/j.ejmech.2019.111789 P2Y purinoceptor 4 1
31727469 10.1016/j.ejmech.2019.111789 P2Y purinoceptor 6 1
31727469 10.1016/j.ejmech.2019.111789 P2Y purinoceptor 1 1
31727469 10.1016/j.ejmech.2019.111789 P2Y purinoceptor 12 1
31727469 10.1016/j.ejmech.2019.111789 P2Y purinoceptor 14 1

Data from ChEMBL 36 via Core Engine