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Compound Detail

CHEMBL4786464

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CNC(=O)[C@@H]1CCCN1S(=O)(=O)c1cccc(COc2cccc3c(C(F)(F)F)cc(C)nc23)c1

Basic Information

ChEMBL ID CHEMBL4786464
Phase Preclinical
Structure Type MOL
InChI Key ODYMQPRHMZQICQ-FQEVSTJZSA-N
0
Targets
0
Activities
0
Assay Types
2
PK Parameters
3
Publications
0
Known Names

Molecular Properties

507.5
MW (Da)
4.04
ALogP
5
HBA
1
HBD
88.6
PSA (Ų)
0.54
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H24F3N3O4S
MW 507.53
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -1.63

Pharmacokinetic Data

Parameter Value Units Species
CL 50.0 mL.min-1.kg-1 Homo sapiens
CL 766.67 mL.min-1.kg-1 Mus musculus

Literature References

PubMed DOI Target Context # Activities
31101472 10.1016/j.bmcl.2019.05.015 Nuclear receptor ROR-gamma 4
31101472 10.1016/j.bmcl.2019.05.015 ADMET 2
31101472 10.1016/j.bmcl.2019.05.015 Unchecked 1

Data from ChEMBL 36 via Core Engine