Compound Detail
CHEMBL4788079
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Basic Information
| ChEMBL ID | CHEMBL4788079 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UBNQTGCQLMZTOD-SWLSCSKDSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
276.3
MW (Da)
1.88
ALogP
4
HBA
1
HBD
50.8
PSA (Ų)
0.90
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 5.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuronal acetylcholine receptor; alpha3/beta4 CHEMBL1907594 | Ki | 5.06 | 5.06 | 8700.0 | 1 |
| Neuronal acetylcholine receptor; alpha4/beta2 CHEMBL1907596 | Ki | 4.34 | 4.34 | 46000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuronal acetylcholine receptor; alpha3/beta4 | Ki | = | 8700.0 | nM | 5.06 | Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 ce... | 33325696 |
| Neuronal acetylcholine receptor; alpha4/beta2 | Ki | = | 46000.0 | nM | 4.34 | Displacement of [3H]-Epibatidine from alpha4beta2 nAChR in rat cerebral cortex m... | 33325696 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33325696 | 10.1021/acs.jmedchem.0c01150 | Unchecked | 1 |
| 33325696 | 10.1021/acs.jmedchem.0c01150 | Neuronal acetylcholine receptor subunit alpha-7 | 1 |
| 33325696 | 10.1021/acs.jmedchem.0c01150 | Neuronal acetylcholine receptor; alpha3/beta4 | 1 |
| 33325696 | 10.1021/acs.jmedchem.0c01150 | Neuronal acetylcholine receptor; alpha4/beta2 | 1 |
Data from ChEMBL 36 via Core Engine