Compound Detail
CHEMBL4789268
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1cc(C)cc(N2C=Nc3cc(Cl)c(-c4cccc(O)c4)cc3C2C(=O)N(C)C[C@H](C)N)c1
Basic Information
| ChEMBL ID | CHEMBL4789268 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JEZABFIGBDYTFL-MDYZWHIJSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
477.0
MW (Da)
5.36
ALogP
5
HBA
2
HBD
82.2
PSA (Ų)
0.52
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 6 meas. best 7.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 2 CHEMBL1804 | EC50 | 7.42 | 7.41 | 38.0 | 4 |
| Somatostatin receptor type 4 CHEMBL1853 | EC50 | 6.02 | 6.01 | 960.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 2 | EC50 | = | 38.0 | nM | 7.42 | Agonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction i... | 32738999 |
| Somatostatin receptor type 2 | EC50 | = | 38.0 | nM | 7.42 | Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as in... | 36655128 |
| Somatostatin receptor type 2 | EC50 | = | 39.81 | nM | 7.4 | Agonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction i... | 32738999 |
| Somatostatin receptor type 2 | EC50 | = | 39.81 | nM | 7.4 | Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as in... | 36655128 |
| Somatostatin receptor type 4 | EC50 | = | 960.0 | nM | 6.02 | Agonist activity at human SST4 receptor expressed in CHO-K1 cells assessed as in... | 36655128 |
| Somatostatin receptor type 4 | EC50 | = | 1000.0 | nM | 6.0 | Agonist activity at human SST4 receptor expressed in CHO-K1 cells assessed as in... | 36655128 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32738999 | 10.1016/j.bmcl.2020.127391 | Somatostatin receptor type 2 | 2 |
| 36655128 | 10.1021/acsmedchemlett.2c00431 | Somatostatin receptor type 2 | 2 |
| 36655128 | 10.1021/acsmedchemlett.2c00431 | Somatostatin receptor type 4 | 2 |
Data from ChEMBL 36 via Core Engine