Compound Detail
CHEMBL4789418
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Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4c3c(N)nn4C(=O)CCCCCCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)cc2)c1
Basic Information
| ChEMBL ID | CHEMBL4789418 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HAQNOFVRIRROBH-RVQPDCMISA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
1056.4
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.09 | 7.09 | 80.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 80.42 | nM | 7.09 | Inhibition of recombinant human N-terminal GST-tagged VEGFR2 (789 to end residue... | 32750566 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32750566 | 10.1016/j.ejmech.2020.112654 | Vascular endothelial growth factor receptor 2 | 1 |
| 32750566 | 10.1016/j.ejmech.2020.112654 | EA.hy 926 | 1 |
| 32750566 | 10.1016/j.ejmech.2020.112654 | HEK293 | 1 |
Data from ChEMBL 36 via Core Engine