Compound Detail
CHEMBL4789532
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O=C1NC(=O)/C(=C/c2cccc(Oc3cc(OC4CCN(C(=O)OCc5ccccc5)CC4)ncn3)c2)S1
Basic Information
| ChEMBL ID | CHEMBL4789532 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BCGLDHYFBLGDSL-HMAPJEAMSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
532.6
MW (Da)
4.77
ALogP
9
HBA
1
HBD
120.0
PSA (Ų)
0.43
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.81
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucose-dependent insulinotropic receptor CHEMBL5652 | EC50 | 6.81 | 6.81 | 153.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucose-dependent insulinotropic receptor | EC50 | = | 153.4 | nM | 6.81 | Agonist activity at human GPR119 stably transfected in CHO-K1 cells assessed as ... | 33611013 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33611013 | 10.1016/j.bmc.2021.116071 | Glucose-dependent insulinotropic receptor | 2 |
Data from ChEMBL 36 via Core Engine