Compound Detail
CHEMBL4796985
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Basic Information
| ChEMBL ID | CHEMBL4796985 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BLIZGFRNWCLCQF-FNORWQNLSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
376.4
MW (Da)
4.66
ALogP
3
HBA
2
HBD
70.7
PSA (Ų)
0.54
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NT-3 growth factor receptor CHEMBL5608 | IC50 | 6.22 | 6.22 | 597.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NT-3 growth factor receptor | IC50 | = | 597.3 | nM | 6.22 | Inhibition of TrkC (unknown origin) using Tyr1 peptide as substrate in presence ... | 32702585 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32702585 | 10.1016/j.ejmech.2020.112552 | High affinity nerve growth factor receptor | 1 |
| 32702585 | 10.1016/j.ejmech.2020.112552 | BDNF/NT-3 growth factors receptor | 1 |
| 32702585 | 10.1016/j.ejmech.2020.112552 | NT-3 growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine